2 edition of Immunity and tolerance in oncogenesis found in the catalog.
Immunity and tolerance in oncogenesis
Conference on Immunity and Tolerance in Oncogenesis, University of Perugia 1969
|LC Classifications||RC261 A277 1969|
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family. Indeed, many IRF members play central roles in the cellular Cited by: This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation.
The progression of pancreatic oncogenesis requires immune-suppressive inflammation in cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance Cited by: 2. Central & Peripheral Tolerance; 3. Immune Regulation in Pregnancy; 4. Breaking Tolerance: Autoimmunity & Dysregulation; 5. Mucosal Immunity & Immunopathology; 6. Regulation of Immunity & the Microbiome; 7. Epigenetics & Modulation of Immunity; 8. Inflammation and autoinflammation; 9. T cell mediated autoimmune diseases; Antibody-mediated.
Immune tolerance: A state of unresponsiveness to a specific antigen or group of antigens to which a person is normally responsive. Immune tolerance is achieved under conditions that suppress the immune reaction and is not just the absence of a immune response. Immune tolerance can result from a number of causes including: Prior contact with the same antigen in fetal life or in the newborn period when the immune . Recent studies have shown that innate immunity is closely related to the HCC carcinogenesis. An effective innate immunity response relies on the toll-like receptors (TLR) found in several different liver cells which, through different ligands and many signaling pathways can elicit, not only a pro-inflammatory but also an oncogenic or anti-oncogenic by:
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Symposium Immunity and Tolerance (Cold Spring Harbor Symposia On Quantitative Biology) 1st Edition by Michel Nussenzsweig (Editor), Anne O'Garra (Editor), Stephen Smale (Editor), David Stewart (Editor), Bruce Stillman (Editor) & 2 moreFormat: Paperback.
Immunity and tolerance in oncogenesis. Perugia, Division of Cancer Research [Perugia Univ.] (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Lucio Severi; Università di Perugia. Divisione di ricerche sul cancro.
With the data presented in this book, we believe to have contributed to the knowledge on the role of immune effector cells, such as dendritic cells, in maintaining the subtle balance between immunity and : Nathalie Cools, Peter Ponsaerts, Viggo Van Tendeloo.
Induction and maintenance of T cell tolerance requires PD-1, and its ligand PD-L1 on nonhematopoietic cells can limit effector T cell responses and protect tissues from immune-mediated tissue damage. The PDPD-L pathway also has been usurped by microorganisms and tumors to attenuate antimicrobial or tumor immunity and facilitate chronic Price: $ Triggering immunity and tolerance to HBV HBV infection, unlike many other viruses, is characterized by a delayed kinetics of viral replication and spread.
Experimental data collected, mainly in animal models but also in humans [ 11 ], showed that HBV replication is detectable in the serum or the liver of infected host only 4–7-week post-infection [ 11 – 16 ] (Fig. (Fig.1). 1).Cited by: 9. Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March.
provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major.
Chronic low level LPS drives IL10 synthesis, PDL1 and T cell Tolerance. Blood enters the liver via sinusoids supplied by the hepatic artery and portal vein. This blood from the intestine is rich in microbial-derived, TLR-activating factors that regulate innate immunity and IL10 by: Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world.
In this context, resistance is defined as the inverse of the parasite burden; when resistance increases, the level of pathogen will decrease. Tolerance is defined by the slope of the reaction norm; the more tolerant the host, the flatter the slope will be 7–8.
In other words, more tolerant plants will exhibit a smaller decrease in their overall health as parasite burden increases compared with non-tolerant by: Immune tolerance or immunological tolerance is the process by which the immune system does not attack an antigen.
It can be either 'natural' or 'self tolerance', in which the body does. Cancer Res. 31, (). A.G. ALLISON, On the absence of tolerance in virus oncogenesis.
In Immunity and Tolerance in Oncogenesis, Proceedings of the 4th Perugia Quadrennial International Conference on Cancer (Edited by L. SEVERI), pp. ().Cited by: In this book, we will address two aspects of peripheral tolerance: self-tolerance and experimental tolerance.
Peripheral self-tolerance as it exists in a normal, healthy animal refers to the lack of an immune response to self antigens in the animal's tissues. A failure in peripheral self-tolerance can lead to autoimmunity.
On Immunity: An Inoculation Eula Biss, the author of "On Immunization: An Inoculation" is the daughter of a poet and a doctor.
She is herself a poet and a renowned essayist, this creates a seemingly absurd but interesting background that I think allows her to bring a unique perspective to an issue that could be otherwise tedious and dull/5. Recently, understanding of oncogenesis has changed its dimension, apart from tumor cells.
Tumor microenvironment (TME) also plays a major role in tumor progression and its immunology. TME constitutes fibroblasts, stromal cells, immune cells, and endothelial cells, which actively take part in oncogenesis and immunology of : Sunil Paramel Mohan, Manoj K Bhaskaran, Ashford L George, Abhilash Thirutheri, Maya Somasundaran, An.
Contents 1 Introduction 2 Self and Nonself 3 The Structure of the Immune System 7 Immune Cells and Their Products 19 Mounting an Immune Response 24 Immunity: Natural and Acquired 28 Disorders of the Immune System 34 Immunology and Transplants 36 Immunity and Cancer 39 The Immune System and the Nervous System 40 Frontiers in Immunology 45 Summary 47 GlossaryFile Size: 2MB.
Purchase Progress in Immunology VI - 1st Edition. Print Book & E-Book. ISBNSkip to content. Oncogenesis and Tumor Immunity Its Role in the Induction of Tissue Immunity and Allograft ToleranceBook Edition: 1. Although tolerance may be induced in all lymphocyte populations, CD4+ T cell self tolerance is the most important and occurs at a far lower antigen threshold than that for B and CD8+ cells.
Mechanisms of tolerance to self-antigens (i) Central tolerance by clonal deletion: Central tolerance refers to mechanisms of tolerance acting during.
B Cells in Immunity and Tolerance. Title B Cells in Immunity and Tolerance. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell Rating: % positive.
TNFAIP8 and oncogenesis TNFAIP8, also known as SCC-S2, GG and MDC, the first identified member of this family, was originally discovered in a primary human head and neck squamous cell carcinoma (HNSCC) cell line and its matched metastatic HNSCC-derived cell line from the same patient by analyzing the expression profile (Patel et al Cited by: The IRF Family Transcription Factors in Immunity and Oncogenesis (Annual Review of Immunology Book 26) Kindle Edition by Tomohiko Tamura (Author), Hideyuki Yanai (Author), David Savitsky (Author), Tadatsugu Taniguchi (Author) & 1 more Format: Kindle EditionPrice: $.
MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.Immunological Tolerance and Regulation focuses on tolerance mechanisms, their exploitation and their avoidance, and aims to attract work in this rapidly evolving field of immunology.
The Specialty section is one in a series of many that deal with “immunology” and aims at avoiding present day “editorial policies” that are not solely. In this Review, Yarchoanet al.
discuss the potential of targeting tumour-specific antigens (neoantigens) to increase antitumour immunity and present a framework for personalized cancer Cited by: